> U.S. Regulators Warn "Safe and Effective" GLP-1 Drugs Carry Possible Blindness Risk

U.S. regulators are requiring the makers of blockbuster drugs like Ozempic and Zepbound to include warnings about a rare eye condition that can cause permanent vision loss.

Dozens of patients have sued Novo Nordisk and Eli Lilly, the biggest makers of these drugs, arguing the medications caused them to lose vision. The companies are fighting the lawsuits and have said studies don’t prove any GLP-1s cause NAION.

A spokeswoman for Eli Lilly said patient safety is its top priority, adding that the company is evaluating the update from the FDA and will respond soon. Novo Nordisk and Sanofi, which also have approved GLP-1s, didn’t immediately respond to requests for comment.

The FDA initiated a review of this possible side effect after first identifying a possible connection in late 2024. The agency reviewed studies involving more than 134,000 patients, along with reports of adverse events, and said it found evidence of a potential increased risk.

https://www.wsj.com/health/pharma/u-s-r … amp;page=1